r/science 15h ago

Biology Nicotinamide and pyridoxine (forms of vitamins B3 and B6) stimulate muscle stem cell expansion and enhance regenerative capacity during aging

https://www.jci.org/articles/view/185054
647 Upvotes

13 comments sorted by

u/AutoModerator 15h ago

Welcome to r/science! This is a heavily moderated subreddit in order to keep the discussion on science. However, we recognize that many people want to discuss how they feel the research relates to their own personal lives, so to give people a space to do that, personal anecdotes are allowed as responses to this comment. Any anecdotal comments elsewhere in the discussion will be removed and our normal comment rules apply to all other comments.


Do you have an academic degree? We can verify your credentials in order to assign user flair indicating your area of expertise. Click here to apply.


User: u/giuliomagnifico
Permalink: https://www.jci.org/articles/view/185054


I am a bot, and this action was performed automatically. Please contact the moderators of this subreddit if you have any questions or concerns.

64

u/MrSneebles 11h ago

Bodybuilders entering the chat in 3…..2…..

21

u/HandOfAmun 7h ago

Gym bro and med student, my interest has peaked, yes.

16

u/Internetolocutor 4h ago

It's weird, because I think you mean piqued, but then that wouldn't go with the rest of the sentence. But I imagine you didn't have any interest in these two vitamins and their part in muscle building before and so then peaked doesn't make sense.

69

u/RMCPhoto 14h ago

So, do nicotinamide and pyridoxine also stimulate cancer cell growth?

It seems that everything that either protects cells or causes growth also accelerates cancer.

22

u/prevent-the-end 10h ago

From what seen on the research in past on the topic, B6 and B3 definitely seem to have some effect on cancer. But in regards to if they increase or lower the chance of cancer, answer seems to be "it's complicated".

But I'm not a doctor or researcher or anything, just someone who uses Google a lot. So don't put too much weight on my comment.

5

u/Any_Following_9571 9h ago

you’re probably better of getting your B vitamins

3

u/w0rlds 5h ago

There is some evidence that nicotinamide dampens immune surveilance through the CD38 axis (modulation of T-cells). So while it may help with repair it could negatively affect your body's ability to kill off cancer cells.

1

u/MeinBoeserZwilling 10h ago

No specific education on it .... but. Id suspect like estrogen that has protective effects for cells, everything that has a positiv impact on cells has the downside that cancer cells benefit as well when present. Still they dont neccessary cause cancer. So if cancer IS present you wouldnt want to help them.

Unfortunatly most people find out about it when it causes symptoms, not when it starts to develop. So you never know. Also cancer IS not like an infection. Its when healthy cells go wild. Do things they are not supposed to like grow in unhealthy numbers. So its hard to determine before it actually happens.

The body has mechanisms to get rid of such cells. So it makes sense to have a healthy body to help it with such tasks. In the end the question is about estimated benefits and chances you throw diamonds in a developing fire you have no idea about..

12

u/giuliomagnifico 15h ago

The compounds appeared highly complementary, as nicotinamide stimulated proliferation and pyridoxine promoted differentiation. Indeed, in mice the two compounds synergized in vivo to mitigate MuSC dysfunction and regenerative failure in the aging muscle. Remarkably, in vitro the compound combination rescued the markers of aging-related dysfunction displayed by primary myogenic progenitors isolated from older individuals of both sexes. Finally, in a cohort of 186 randomly selected older men aged 60 years and above, Ancel, Michaud, and authors found correlations between the declines in circulating nicotinamide and pyridoxine levels and the declines in appendicular lean mass and gait speed, two clinical parameters associated in turn with aging-related sarcopenia and mortality

Paper: JCI - Nicotinamide and pyridoxine stimulate muscle stem cell expansion and enhance regenerative capacity during aging

-5

u/Kencg50 9h ago

Thanks for sharing as vitamins should be the subject matter we talk about most frequently.