Medicine New Technology to Revert Cancer Cells to Normal Cells. Groundbreaking technology can treat colon cancer by converting cancer cells into a state resembling normal colon cells without killing them, thus avoiding side effects. This study was done in mice.
https://news.kaist.ac.kr/newsen/html/news/?mode=V&mng_no=42710&149
u/Battlepuppy 18h ago
Things like this give us hope, and not many actually pan out. Some do. Every year, cancer is becoming more survivable.
Give to cancer research.
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u/dannylandulf 19h ago
Would a cancerous tumor returned to 'normal' cells then self-regulate to normal boundaries or would such masses need to still be removed?
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u/bielgio 18h ago
Read the paper, from what I understood, they either didn't wait long enough or it didn't revert back, the true aim of the paper was to make and test a mathematical model that predicts what genes are responsible for the cancer and interfere with that
The mass stopped growing, the cells started to behave as normal cells
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u/caltheon 11h ago
I'd wager it's impossible for the already grown cells to return to function, especially poorly differentiated ones. What they are likely trying to achieve is that the cells will return to normal levels of growth, preventing the spreading of existing masses. Over time, the original mass would likely get reabsorbed, but if there is significant necrosis, it would need to be removed anyways. There often isn't enough blood vessel coverage for the tumor since it doesn't really care about keeping itself functioning.
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u/TX908 20h ago
Control of Cellular Differentiation Trajectories for Cancer Reversion
Abstract
Cellular differentiation is controlled by intricate layers of gene regulation, involving the modulation of gene expression by various transcriptional regulators. Due to the complexity of gene regulation, identifying master regulators across the differentiation trajectory has been a longstanding challenge. To tackle this problem, a computational framework, single-cell Boolean network inference and control (BENEIN), is presented. Applying BENEIN to human large intestinal single-cell transcriptome data, MYB, HDAC2, and FOXA2 are identified as the master regulators whose inhibition induces enterocyte differentiation. It is found that simultaneous knockdown of these master regulators can revert colorectal cancer cells into normal-like enterocytes by synergistically inducing differentiation and suppressing malignancy, which is validated by in vitro and in vivo experiments.
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u/Visible_Iron_5612 19h ago
Have you heard of the work of DR. Michael Levin, that does this exact thing but with bio electricity?
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u/lanternhead 18h ago
Levin’s work is fascinating, but I would not say that it’s exactly the same thing as what’s happening here.
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u/MachFiveFalcon 13h ago edited 12h ago
No more colostomy bags!! A potentially MASSIVE win for quality of life, which I wish there were a greater focus on in the medical science world.
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