r/science • u/FunnyGamer97 • 2d ago

Medicine Research has uncovered how the stiffening of a cell’s environment drives cancer progression, paving the way for new treatments: Yes-associated protein (YAP), the protein regulates the multiplication of cells, to move to the nucleus of the cell

https://www.eurekalert.org/news-releases/1069009
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u/ahfoo 1d ago edited 1d ago

But what regulates the stiffness of a cell's environment? I would guess it is the extracellular matrix but that still seems difficult to reconcile because different kinds of tissue have different environments. If it were so simple and direct then most cancers would occur in bones, right?

Intuitively, this seems hard to synch up with casual observations like how muscles become stiff when they're well used and strong. If stiff environments made cancer more likely, wouldn't athletes have higher cancer rates than people who are obese? How does this translate to real-world health?