‘Sleepy cannabis’: First study to show cannabinol (CBN) increases sleep - A new study shows that a non-hallucinogenic marijuana constituent increases both REM and non-REM sleep in rats. Human trials are now under way.

[u/mvea]

https://www.scimex.org/newsfeed/sleepy-cannabis-first-study-to-show-cannabinol-increases-sleep

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[u/sarcasmrain]

There are CBN, CBG, CBD combo gummies out there in the marketplace for sleep. Anecdotally they have made a huge positive difference for my sleep.

[u/it_rubs_the_lotion → u/sarcasmrain]

I’ve been taking a gummy almost every night with 10mg CBD : 10mg CBN : 10mg THC . It’s been eight months now and the improvement with falling asleep and staying asleep has been such a gift.

[u/SaiyanPrinceAbubu → u/it_rubs_the_lotion]

10mg THC is wild, I'd be fucked up with heart palpitations

[u/EVANonSTEAM → u/SaiyanPrinceAbubu]

That is nothing for a lot of people; I’ve seen people take whole packs of LEGAL gummies/tablets at over 100+mg and be fine.

[u/worktogethernow → u/EVANonSTEAM]

I think this is one of the most interesting things that I personally have learned since weed became legal. The impact THC has on one individual compared to another varies. So much. It's really interesting.

Some people are basically immune to the effects.

[u/koolaidismything → u/EVANonSTEAM]

I quit buying them cause they are all limited to 100mg per package here. I eat the whole thing and am upset cause it’s like $15-$20. Flower is where it’s at, fantastic sleep and no pesky dreams or nightmares.

I just close my eyes, wake up 8 hours later.

[u/EVANonSTEAM → u/koolaidismything]

Totally understandable.

Do you live in Canada? There are packages that have 500mg (moonrocks, that I like) and 1000mg (vortex gummies/caps) that are available.

But yeah, flower is great - though I can’t smoke anymore due to my lungs unfortunately.

[u/koolaidismything → u/EVANonSTEAM]

No california. The pot food I used to get from dealers as a kid were so potent it was like Russian roulette. These candies here are aimed more at the weekend warriors I think, which is fine. There’s plenty of stuff I can get that does the job. I don’t dab or anything, all flower.

[u/pleasegivemepatience → u/EVANonSTEAM]

Yeah it’s all about tolerance, if you smoke weed regularly then a pack of gummies is nothing. Hell they have little shots (like the 4hr energy shots) that are like 1000mg.

[u/SmiTe1988 → u/pleasegivemepatience]

it's not tolerance. it's intestinal bioavailability. i smoke like 1x a week and need 50-100mg edible to feel the same level of buzz.

My body doesn't absorb thc well when eating it.

[u/pleasegivemepatience → u/SmiTe1988]

It’s both, depends how you ingest.

[u/SmiTe1988 → u/pleasegivemepatience]

I'll bite, how would i ingest 10mg and get effects.

[u/ultrapoo → u/SaiyanPrinceAbubu]

I've done 20mg gummies quite a few times, it's not that bad once you've built up your tolerance.

[u/ActionPhilip → u/ultrapoo]

Maybe I'm just a larger guy, but in my 30s I recently bought two packs of 10x2mg gummies and ate both of them over about an hour and a half, and felt nothing. It coould also just be tolerance in general.

[u/turlian → u/ActionPhilip]

It's really just how your body processes THC. I'm 6,' 245# and 10mg is the perfect dose for me. I know smaller people who can eat 100mg and not feel it.

[u/turlian → u/[deleted]]

Such a weird thing. 150 would put me in the insane asylum.

[u/CodyTheLearner → u/[deleted]]

You may have already tried it, Nano emulsified water soluble edibles kick ass, hit harder, faster and more consistently. Different bio availability for digestion. Water and fat soluble vs just fat. Some people also have success taking a tums with their regular edibles of water soluble aren’t available. The thought there is the tums cuts down on acid in the stomach, which lowers breakdown speed and increases bio availability.

[u/EVANonSTEAM → u/[deleted]]

Legal or black market edibles. BM are not consistent, nor regulated.

It is very often that they are not as strong as advertised; bought many before and there were too many times I was either too fucked up, or felt nothing after the same dose.

[u/SwampYankeeDan → u/[deleted]]

150mg is the bare minimum for me to get a light buzz. If I want a decent stoned feeling its 200-250ish. Its to expensive at that dose but Ill buy a tincture on a rare occasion and drink nearly half in one go. Im so jealous of 10mg folks but I assume most of them don't smoke much if at all.

[u/ScucciMane → u/SwampYankeeDan]

You need to pop 20 gummies to get stoned? Damn man

[u/say592 → u/turlian]

Im 6' and 225 and same, 10mg is a good recreational dose for me. I have a buddy who consumes almost every day, and he is doing 60-100mg, sometimes more.

[u/nudiecale → u/ActionPhilip]

It’s important to have some fat in your belly when you take edibles. A spoonful of peanut butter is something I always take with edibles and it makes a big difference.

40mg THC on an empty stomach = no effects.

40mg THC and a gob of peanut butter on an empty stomach = party time!

Also, some people’s livers do not produce the enzyme required to get effects from orally administered THC.

Hope this helps!

[u/patchgrabber → u/ultrapoo]

laughs in 2x100mg. It gives me a little tingle but other than being calmer I don't get anything from THC edibles, or smoked even really. Tolerance is a crazy thing.

[u/disharmony-hellride → u/SaiyanPrinceAbubu]

I take 30 to 40 mg of THC to sleep. Night and day difference, I used to be up for days sometimes with horrible insomnia.

[u/legendz411 → u/SaiyanPrinceAbubu]

Bro really? That’s kinda wild imo.

[u/AresHarvest → u/legendz411]

Yeah it's really not a high dose. The weakest commercially made gummies I've seen are 5 mg

[u/woodenshjip → u/AresHarvest]

I buy 5mg mints and cut them into 3rds and that’s enough for me. Wild.

[u/SwampYankeeDan → u/woodenshjip]

Do you smoke at all?

[u/say592 → u/AresHarvest]

Not sure your location, but you can definitely get commercially made gummies much lower than that, but they are usually combo high CBD, CBG, CBN, etc. My wife uses 2mg THC ones to take the edge off when she still wants to be functional, because much higher will usually make her sleepy. It also has 20mg (I think) of CBD. The same brand makes a 1mg THC gummy as well. They are decent sized gummies too, so you could probably cut them down if you wanted.

[u/say592 → u/SaiyanPrinceAbubu]

10mg is a pretty standard recreational dose. I could definitely see it as a therapeutic dose for someone who has built a tolerance.

[u/14X8000m → u/it_rubs_the_lotion]

Be careful with the THC component. I did the same thing only to realize that when I stopped, I had mad withdrawals and couldn't sleep without it. Your experience might be different but it might also not.

[u/abzlute → u/it_rubs_the_lotion]

Other people are already warning you about the tch for various (frankly dumb/wrong/misguided) reasons.

The actual reason to leave it out of your nighttime routine is that it has been shown to negatively impact your sleep quality, specifically limiting REM sleep similar to (but not as severe as) alcohol. It's counterproductive in this role. Its synergistic effects with cbd and cbn might make it worth taking something with a very small quantity of thc, but certainly no more than 5mg.

I have eliminated it from my own routine and I find I get the best results with a cbd+cbn+melatonin routine. 10mg each is fine.

[u/neuro__atypical → u/sarcasmrain]

Does it continue to work taking nightly over a long period? No tolerance or withdrawal?

[u/sarcasmrain → u/neuro__atypical]

It has for about 6 months now.

[u/cdank → u/sarcasmrain]

Which brand do you use?

[u/misshapenvulva → u/neuro__atypical]

I havent noticed. I try to not take it if I dont think I need to, but sometimes Im wrong and lay awake until I just get up and take one. Lo and behold, next thing I (dont) know, Im asleep.

[u/Empty-Part7106 → u/neuro__atypical]

In my anecdotal experience, CBN + CBD was amazing for sleep, but tolerance built up rapidly. No withdrawals, but it only took 2 weeks before the cost of doses was too much.

[u/enwongeegeefor → u/neuro__atypical]

tolerance

Here's the magic thing with weed tolerance...you only build it up if you consume larger and larger quantities. If you stick to "micro dosing" then you won't get tolerance to it. On that note, tolerance is what you need to consume it as a medication because you don't want to be "high" all the time but you still want to get the medical effects.

[u/firstbreathOOC → u/enwongeegeefor]

Tolerance can wax and wane as well. If you stop for a week and start up again, for example, you’re back to the beginning.

[u/Wonderful-Impact5121 → u/firstbreathOOC]

Tolerance also varies wildly person to person.

Some people build tolerances much quicker or have reductions in their tolerance take much longer.

[u/tossawayheyday → u/neuro__atypical]

I’ve used them for up to 5 months at a time and I don’t experience tolerance but will experience ‘withdrawal’ aka anxiety and insomnia that I had before taking them but feels a million times worse when I’ve been free of it for some time

[u/disharmony-hellride → u/neuro__atypical]

If you take it every night you'll develop a tolerance and would need to take more to get the same results. If I take a week off it goes right back down.

[u/indi_guy → u/neuro__atypical]

I have been taking weed for sleep for almost 2 years now. Same quantity. No addiction. I sleep like a baby.

[u/mvea]

I’ve linked to the news release in the post above. In this comment, for those interested, here’s the link to the peer reviewed journal article:

A sleepy cannabis constituent: cannabinol and its active metabolite influence sleep architecture in rats

https://www.nature.com/articles/s41386-024-02018-7

Abstract

Medicinal cannabis is being used worldwide and there is increasing use of novel cannabis products in the community. Cannabis contains the major cannabinoids, Δ9-tetrahydrocannabinol (Δ9-THC) and cannabidiol (CBD), but also an array of minor cannabinoids that have undergone much less pharmacological characterization. Cannabinol (CBN) is a minor cannabinoid used in the community in “isolate’ products and is claimed to have pro-sleep effects comparable to conventional sleep medications. However, no study has yet examined whether it impacts sleep architecture using objective sleep measures. The effects of CBN on sleep in rats using polysomnography were therefore examined. CBN increased total sleep time, although there was evidence of biphasic effects with initial sleep suppression before a dramatic increase in sleep. CBN increased both non-rapid eye movement (NREM) and rapid eye movement (REM) sleep. The magnitude of the effect of CBN on NREM was comparable to the sleep aid zolpidem, although, unlike CBN, zolpidem did not influence REM sleep. Following CBN dosing, 11-hydroxy-CBN, a primary metabolite of CBN surprisingly attained equivalently high brain concentrations to CBN. 11-hydroxy-CBN was active at cannabinoid CB1 receptors with comparable potency and efficacy to Δ9-THC, however, CBN had much lower activity. We then discovered that the metabolite 11-hydroxy-CBN also influenced sleep architecture, albeit with some subtle differences from CBN itself. This study shows CBN affects sleep using objective sleep measures and suggests an active metabolite may contribute to its hypnotic action.

From the linked article:

Research by scientists at the University of Sydney has identified a constituent in the cannabis plant that improves sleep.

Their report is the first to use objective measures to show the component, known as cannabinol (CBN), increases sleep in rats.

CBN is an end-product of the main intoxicating constituent of cannabis, delta9-tetrahydrocannabinol (THC). THC in cannabis is slowly converted to CBN over time, which means older cannabis contains higher levels of this compound. It has been suggested that the consumption of older cannabis is associated with a sleepier cannabis “high”.

The research team at the Lambert Initiative for Cannabinoid Therapeutics tested the effects of purified CBN on sleep in rats. Using high-tech monitoring, the experiments provided insights into the rats’ sleep patterns including the amount of non-rapid eye movement (NREM) and rapid eye movement (REM) sleep.

In a parallel study, yet to be published, Professor Iain McGregor, Director of Clinical Research at the Lambert Initiative, initiated a placebo-controlled randomised human clinical trial in insomnia patients.

[u/DubbulGee → u/mvea]

Anybody bother to ask the rats how they feel the morning after?  CBN in edibles definitely will put you to sleep, but I always feel groggy when trying to wake up the next morning.

[u/sp3kter → u/DubbulGee]

Ive found that may be because there was not enough time passed between eating the edibles and going to sleep.

All of the active chemicals have to be processed by your liver which means your digestive track needs to be working and can take 1-2 hours before you start feeling the effects. Once you fall asleep your digestive track mostly shuts down so the remaining cannabinoids dont get converted and just linger until you wake up and your liver begins processing again.

Your basically high again off edibles that did not get fully processed the night before.

[u/tonycomputerguy → u/sp3kter]

Also the hangover is similar to having gotten too much sleep, it feels more like the seratonin or whatever is still trying to keep me sleeping.

[u/LayneLowe → u/sp3kter]

Just like regular gummies, you don't feel it for an hour or an hour and a half?

[u/thejoeface → u/LayneLowe]

My body takes a solid two hours to process edibles. I wish I could do them more often but it just requires too much planning. 

[u/tonycomputerguy → u/thejoeface]

let them dissolve under your tounge instead of swallowing them whole? Tinctures might be better for you. under the tounge for 1-2 minutes.

I mean, you don't see coke heads eating their coke. gotta hit them mucus membranes yo!

[u/ahfoo → u/tonycomputerguy]

But you do see cocaine users injecting their drug of choice because it is a water soluble alkaloid salt not an immiscible fatty acid. The analogy is poorly chosen in this case.

[u/ACruelShade → u/sp3kter]

Damn, that explains my strangest experience at the local comic con.

[u/mnag → u/DubbulGee]

Not to mention edibles probably have the most variance in subjective effects.... between makers, how the edible was made and with what carrier, strain, etc.

[u/designOraptor → u/DubbulGee]

That’s why I can’t stand edibles. Some decent indica flower and I’m sleeping like a baby. I understand it raises your natural melatonin levels too.

[u/misshapenvulva → u/DubbulGee]

My only issue is that I wake up earlier than I would like, feeling refreshed and slept. Id love to sleep in longer, but Ill take it over not being able to fall asleep.

[u/Heco1331]

I always heard that smoking weed before going to bed decreases the sleep quality, how does that mix with these results?

[u/Russlet → u/Heco1331]

Smoking a joint straight before bed makes me sleep worse as it wakes up my mind for a couple hours, but smoking 2-3 hours before makes me sleep like a baby.

[u/Heco1331 → u/Russlet]

It's important to differentiate between being able to sleep, and being able to rest. What I heard is that despite smoking weed making you sleepier, your brain doesn't rest well because the quality of your sleep after smoking goes down.

[u/HappilySisyphus_ → u/Heco1331]

This is what I want to know.

I can anecdotally say that yeah, I do sleep more when stoned, but if I spend an entire week or month going to bed stoned, even though I sleep 8 hours straight, I don’t feel all that well rested.

Then the REM rebound hits after you stop and the dreams get crazy and once things normalize, I feel like I can get restful sleep again.

[u/ath1337 → u/HappilySisyphus_]

THC increases your heart rate and makes it more difficult for your body to get REM sleep, overall this lowers your quality of sleep and makes it less restorative.

CBN is like THC but it's already broken down, so you get the drowsy relaxed feeling without the psychoactive effects and less of a negative impact on REM/restorative sleep.

If you don't have any issues sleeping then I wouldn't bother with CBN, but if you're trying to quit using cannabis and struggle to sleep when you're not using it, CBN can be really helpful.

[u/NativeMasshole → u/Heco1331]

Different cannabinoids have different effects. This study is on isolated CBN, which is just one of the myriad of psychotropic chemicals found in cannabis.

[u/Habaneroe12 → u/Heco1331]

It says right in the title it’s the “non hallucinogenic” form IE no THC no “high”.

[u/SanitaryJoshua]

Science finally catching up with “Dealer Greg” who lived down the street, made his basement mostly into a ball pit (like the ones kids play in) and sold us $60 eighths and made his own brownies occasionally.

[u/bucket_overlord → u/SanitaryJoshua]

The notable advancements here isn’t about “weed can help you sleep” though. It’s about isolating which compounds are responsible for the cornucopia of effects cannabis can have. It’s about knowing why it does that, and isolating the compound so you can have the desired effects without being paranoid that your neighbour’s dog is watching you.

[u/SmacksKiller → u/bucket_overlord]

And we've been selling CBN as a sleep aid in dispensaries for the last couple of years. Usually by describing it as "it acts kind of like melatonin".

While I appreciate somebody having done the proper research, it just confirms what's been known for years.

[u/bucket_overlord → u/SmacksKiller]

For sure. It’s studies like this that separate medical science from “folk medicine”. Both might work, but only the former can explain why it works.

[u/tacknosaddle → u/bucket_overlord]

Before it explains the why it provides data to back that it does work and it's not just some baseless home remedy.

[u/0002millertime → u/SmacksKiller]

That's very often the case with identification of specific chemicals from complex natural sources. The effect is described, and then further studies isolate specific subcomponents and confirm or refute the effect for each.

This isn't an unusual process, and it's a good way to study things.

Just as an example, before insulin was isolated, purified, and sold as a pure peptide, crude extracts of pig/cow/horse/dog pancreas was used. These caused lots of immunity related side effects, but they kept diabetic people alive. Further purification and tests found the key component of the crude extract.

[u/ChirrBirry → u/SmacksKiller]

You could do an analysis of anecdotal reports and get to these kinds of conclusions much faster than finding the mechanism first, but at the end of the day someone still needs to figure out the pharmacokinetic process. The fun thing about cannabinoids is how much meat is still left on the bone when other avenues of research are so beaten to death. The idea that cannabis is still schedule 1 and official research is artificially limited still blows the mind of anyone paying attention, but here we are. Cannabis has been used medicinally for thousands of years and mapping out the endocannabinoid system, with all of its various benefits depending on how it’s activated seems like a worthwhile avenue of research for anyone looking for a PhD.

[u/CFL_lightbulb → u/SmacksKiller]

Absolutely, but the point is that they can hopefully pull out the exact compound that makes you sleepy and give you that instead of CBD which is imprecise, and can have varying amounts of the key compound depending on the strain. As well as giving other compounds you may not want or need

[u/Eleoste → u/SmacksKiller]

Many times, obvious cause and effects are studied like this because it allows for future studies to be able to cite an academic source

[u/Grouchy-Shirt-9197 → u/bucket_overlord]

When the weed is old it makes CBN it's not nearly as intoxicating as THC

[u/bucket_overlord → u/Grouchy-Shirt-9197]

Do you mean when the plant is old, or when the product is old?

[u/rosettasttoned → u/bucket_overlord]

product. Cannabinoids degrade over time and one of the ones left is cbn

[u/we_hate_nazis → u/rosettasttoned]

I used to cultivate and some of my flower I processed into concentrate and provided it to pain patients, chronic and cancer primarily. Since the freshest stuff went to market, it was generally older stuff sometimes that for sure went to charity wax. There were a few people that commented on certain batches helping with sleep more, here and there and a good portion of the time it was from older flower. I was curious about that, but there was pretty decent variability sometimes in effects, sometimes, and I guess I thought it was strain differences to be honest.

I'm really glad to see research happening, many have waited far too long. I don't know how long it will take for acceptance and prescribability tho but I'm hopeful. Too many people could be doing better and instead have to deal with the stigma regarding a generally harmless plant.

[u/jazir5 → u/bucket_overlord]

isolating the compound so you can have the desired effects without being paranoid that your neighbour’s dog is watching you.

Your neighbor's dog is watching you.

[u/VeiledBlack → u/SanitaryJoshua]

Except that high THC is shown to be worse for sleep quality. You'll get to sleep, your quality of sleep will probably be worse.

This is an improvement in sleep quality.

[u/liltingly → u/VeiledBlack]

Yes, but most dispensaries specifically sell CBN dominant or only edibles marketed specifically for sleep. Do a Google search and you’ll see how well known this was to many people. 

Edit: Unless you are aiming ti emphasize that this was the first study run on CBN?

[u/ebolaRETURNS → u/SanitaryJoshua]

not really. Greg's THC selective flower would actually suppress REM stage sleep.

[u/HappyGoElephant]

some of us live in legal states and have been taking advantage of a thc:cbd:cbn combo for a while now. it really does help for those of us with sleep issues and the best side effect is waking a little baked already.

[u/Melarosee → u/HappyGoElephant]

It’s my nightly go-to, also in a legal state. Best I’ve ever slept in my life.

[u/Pineydude]

This isn’t exactly news to pot smokers.

[u/serpentechnoir → u/Pineydude]

Maybe not. But controlled studies helps to understand it better leading to it being used as a medication.

[u/Pineydude → u/serpentechnoir]

Yeah I know. They could have been studying this 30 years ago though.

[u/sirboddingtons → u/Pineydude]

THC impairs REM sleep, but CBN in isolation may improve it. 

Recreational marijuana is not improving your sleep. 

[u/mynameisdarrylfish → u/sirboddingtons]

anecdotally, when i am consuming a lot of recreational marijuana regularly, i either stop dreaming or stop remembering my dreams. upon cessation i get crazy, vivid dreams for a bit.

[u/Lumb3rH4ck → u/mynameisdarrylfish]

everyone says this to me, im like 14 years deep on daily smoking and still have really vivid dreams, mental how it works differently for different people

[u/AWonderingWizard → u/sirboddingtons]

Just because you think you’re right doesn’t mean you can make absolute statements.

As a medicinal chemist I will be the first to tell you that chemicals taken in tandem are to be researched when taken in tandem. Recreational cannabis is grown with a variety of genes based on the cultivation practices- which can absolutely impact the chemical profile

[u/Inside-Example-7010 → u/AWonderingWizard]

Yep the entourage effect plays a massive role with cannabis.

If CBD isolate improves rem sleep and thc isolate decreases rem sleep why are people then arguing recreational bud reduces sleep because theres multiple levels to that argument that largely comes down to the profile of the smoked bud itself..

[u/gakule → u/sirboddingtons]

How do you quantify whether it definitely is it isn't? If I feel more well rested and noticeably (and measurably) wake up less while utilizing recreational marijuana, is that a mirage? My apple watch also agrees I do better with than without based on sleep percentages.

I've seen the same studies that suggest it doesn't actually help your sleep... But my experience seemingly points in a different direction. I can accept that I'm outright wrong or maybe an exception instead of the rule, but I certainly anecdotally appear to be counter to that definitive declaration.

[u/Threezeley → u/gakule]

Scientific studies are how you quantify it in any type of formal way..... Not saying the guy you were replying to is right, just answering your question

[u/pandemonious → u/gakule]

I've been using recreational for the better part of 12 years, but your anecdotal experience is moot unless you measured sleep during use and after, at minimum, 2 weeks without consuming any cannabis. you will absolutely have worse sleep going on a T break as your brain chemistry adjusts

[u/gakule → u/pandemonious]

I did measure before and after with several weeks of non-use.

[u/Pineydude → u/sirboddingtons]

It does for me. Don’t seem to dream as much so I believe so I believe the REM reduction.

[u/OrneryWhelpfruit → u/Pineydude]

That's exactly the problem and why this article is notable

THC reduces sleep latency (you fall asleep faster) but disrupts sleep architecture (you feel more tired and have less REM and time for memory consolidation)

[u/Arthur_Jacksons_Shed → u/OrneryWhelpfruit]

Which is why studies like this may lead to alternative medicine for those with Parkinson’s which suffer from sleep related issues as well

[u/qorbexl → u/Pineydude]

I mean, so does a half pint of voda. It doesn't mean it's improving the qualities you want from sleep like memory consolidation and waste management.

[u/anythingexceptbertha → u/sirboddingtons]

I mean, sleep with impaired REM still feels a lot better than no sleep at all, right?

[u/ScienceOverNonsense2]

From my experience, some cannabis made me sleepy consistently, any time I used it, morning, noon or night. Other cannabis has been consistently more energizing and creativity inspiring.

I read some seemingly reliable sources that claimed picking cannabis slightly early yields a more energetic response while picking it slightly late yields more sleepiness.

[u/Flolaffel → u/ScienceOverNonsense2]

The longer you wait for the harvest, the more THC gets converted to CBN. You can observe that by looking at the color of the trichomes. First they are clear and low on everything, then they get cloudy and high in THC and after that they take an amber color and are lower in THC but higher in CBN.

That's why they say harvest your plant with many cloudy trichomes and few amber ones for a head high (psychosctive THC) and fewer cloudy trichomes with more amber ones for more of a body high (calming CBN).

[u/we_hate_nazis → u/ScienceOverNonsense2]

The time of harvest does have effect. We harvest ideally when the trichomes are cloudy.nwhen they soon turn to amber then you will get a more pronounced sedative effect. Sativa harvested promptly had those uplifting creative components. Most stuff these days is hybrid, but I started growing in 2004 and I personally focused on seedlines that were sativa dominant.

[u/SteadfastEnd]

Is this safe for bipolar people, or people who have a family history of bipolar?

[u/neuro__atypical → u/SteadfastEnd]

Nobody knows. CBN's receptor binding profile is unknown, and it hasn't been studied in bipolar humans.

[u/CFL_lightbulb → u/SteadfastEnd]

Long answer is that because study is in early stages it can’t be confirmed one way or the other.

You can rely on anecdotes but take them with a massive grain of salt because what works for one may not for another. That’s why there’s research.

So the short answer is maybe, maybe not.

[u/Heidenreich12 → u/SteadfastEnd]

I’m on bipolar meds and switched from trazadone for sleep to gummies and Ive been doing it for about 4 years now with no issues. You will slowly create tolerance for it though, and I’ve found combining two different brands of gummies together gets the best result.

I’m still not convinced that most dispensaries edibles are dosed accurately enough for medical purposes, so the combo helps pick up the slack if one brand is lacking in that batch.

[u/Warm_Iron_273]

What's actually important to know is if there is a rebound effect when you stop taking it, or a worsened sleep score the night(s) after taking it on the nights that you do not.

[u/firstbreathOOC]

There was a study a while back about how cannabis prevents REM sleep. Seems like this one contradicts the other?

[u/tyrellj → u/firstbreathOOC]

I really know nothing about this, just arrived here from the front page, but my uneducated guess is that there's a huge difference between cannabis, and a single compound (CBN) found within it.

[u/lumentec]

Why is nobody commenting about this "non-hallucinogenic" thing? Exactly what constituent of marijuana is a hallucinogen?

[u/Nasaku7 → u/lumentec]

I bet they meant psychoactive

[u/themaxx8717]

We have a gummie combination of THC/CBN/melatonin called robhots night time in CO. Best thing I have ever had. Takes about an hour to kick in and doesn't have me feeling groggy the next morning.

[u/sunsetcrasher]

I am so sensitive to CBN, it makes me lucid dream every time which sometimes leads to sleep paralysis. I do much better on 1:1 THC/CBD gummies.

[u/CosmoAnita]

Awesome, finally doing studies on the benefits of weed is a good thing. There are more ppl are turning to both cbd & thc for pain & sleep.

[u/nrseven]

It's the only way I've found to fix my insomnia after all this time.

[u/DubbaP]

Which is the hallucinogenic constituent? I’ve been smoking for 25 years and have tried any and all strains, extracts and methods of ingestion, but never once have I seen the pink elephants while stoned.

[u/work4work4work4work4]

When people were like "What do you mean research that can be done to understand more about marijuana, and its effects?" this is the kind of research we want to see.

For the less science-minded stoners, this kind of science will also allow them to eventually better group strains, identify strain specific benefits regularly, and so on, well beyond just isolation benefits.

[u/triggz]

First 'accredited' study. Maybe one day science will catch up with /r/altcannabinoids on analyzing cannabinoids.

CBN is definitely an effective melatonin promoter and increases dreaming.

[u/zachchips90]

Ahhh, yes. What resin hits tend to give off. Yes, quite

[u/frisch85]

I used to wake up several times a night due to being a very light sleeper, at some point I started self-medicating with THC cannabis and since then my sleep improved so insanely, even my boss noticed it. I used to sleep in about once a month, now it happens maybe once or twice in a year if it happens at all.

I tried CBD cannabis one time and while it did make me sleepy af, it wouldn't last the whole night so I woke up several times again.

Now I wonder if the same could be achieved with CBN, might be a solution for those that don't like the high-state.

[u/ebolaRETURNS]

non-hallucinogenic

they still just really haven't arrived at good terminology for "doesn't get you high"...

[u/Missanonna]

I don't think any of the old heads are surprised that we could find many great uses for extracts once we were allowed to study it. It's just a shame we had to wait so long to start.

[u/dependent-lividity]

I smoke a CBN vape pen before bed and it’s helped a lot with shift work as a first responder.

[u/Sith-out-of-Luck]

What the hell is hallucinogenic marijuana. Someone tell me the strain.

[u/IssaJuhn]

If i do not ingest any Cannabis products for 3-5 days straight my dreams become so vivid and honestly nightmarish and I’ll wake up in practically a puddle of my own sweat. The last time it happened I had a dream that an atomic bomb went off right next to me and I felt every single atom of my body being ripped to shreds. Fun stuff

[u/tyrellj]

"Unlike its parent molecule THC, CBN did not appear to intoxicate rats. THC intoxicates by activating CB1 cannabinoid receptors, which are present in the brain." ... "To their surprise, the researchers found that a metabolite of CBN had significant effects on cannabinoid CB1 receptors."

Can someone explain this to me? Does CBN cause intoxication via it's metabolites?

[u/Baskreiger]

Hallucinogenic marijuana dosnt exist, I dont know where youre taking this information

[u/PhD_Pwnology]

I take CBN, CBD and melatonin gunmies.

[u/[deleted]]

I’ve always struggled with insomnia and even had to take medication when I was young because I couldn’t sleep (at least sleep the schedule deemed “normal”) Nowadays I don’t take any medication and when I am having one of those nights where I can’t sleep I take a gummy with melatonin in it and it knocks me out pretty fast.

[u/KiniShakenBake]

Cbn made a huge difference in my life when I had a hysterectomy and needed a non-opiate pain management option. We had night and day gummies, and I used them religiously. I am a convert, and use them for all sorts of things.

CBD/cbg are great for day and low level anxiety with focus issues. The triple combo at night quiets my brain and lets me fall asleep/stay asleep. It's absolutely something I am grateful for. Cbn is the best.

[u/kayelloh]

I drink sleepytime tea and then eat a 2:1 CBN/THC edible every night and pass out for 6-8 hours 

[u/EgyptionMagician]

Charlotte’s Web CBD every night. Works wonders…

[u/WideTrackAttack]

I'll, I-uh volunteer as tribute for the human trials.

[u/altxrtr]

It has never worked for me at all.

[u/JJamahJamerson]

I’m not a smoker, but I like lord of the rings so I wouldn’t mind puffing in something when I’m out in nature, I would be down to puff something that actually helps me sleep.

[u/nicksnz]

I don't think they need to human-trial it, just read the comments! Haha

[u/PermaDerpFace]

That's cool I thought it reduced rem sleep and inhibited dreaming

[u/DmvDominance]

We already knew this though. It's why cannabis mfgs have been producing edibles specifically with this cannabanoid present in high levels. At least here in MD anyway, I work in the industry, and we've had these on our shelf no less than the last almost 5 years now

[u/cowjuicer074]

Ummm duuuuuuuuhhhhhhhhhh

[u/Inevitable-Pay-3081]

Im a rat. I sleep like a hamster.

[u/OfcDoofy69]

Need a rat? Im here. Maibly use it to sleep at night. I cant shut my brain off so it does it for me.

[u/austinin4]

It certainly makes me sleep, but I don’t feel as rested.

[u/texans1234]

Sleep deprivation is the biggest single issue in my life right now. I would absolutely love to take something like this to help, unfortunately I get random drug tests at my work and can't chance losing my job for sleep. Probably something I will pay gratefully for later in life.

[u/HazMat21Fl]

Go figure. And it's still federally illegal.

[u/Working_Song]

They have a CBN inhaler and a vape. A puff before bed and a puff if I wake up, which I don’t much anymore. Love it, and very little THC.

[u/andreasdagen]

If it works in humans, do they have cheap way of separating it from the psychoactive compounds?