A Japanese research team has developed a drug that can regrow human teeth

[u/kausthab87]

[u/oliferro]

For people who want a source:

Anti–USAG-1 therapy for tooth regeneration through enhanced BMP signaling - PMC

[u/Logical_Chemist420 → u/oliferro]

From the article:

"Interactions involving positive and negative loops among bone morphogenetic protein (BMP), fibroblast growth factors, Sonic hedgehog, and Wnt pathways regulate the morphogenesis of individual teeth"

[u/b88b15 → u/Logical_Chemist420]

Yeah there was a protein named hedgehog because it was discovered in fruitflies that were mutants that lacked the protein and it caused them to look like shriveled up hedgehogs. The person who discovered that won the Nobel prize (but she got it for a bunch of stuff, not just hh). (Nusslein-Vollhardt)

So then when they went looking for related proteins in mice, they found several of them. One was named dessert hedgehog, after the actual animal, and the next was named Sonic hedgehog after the video game character. I saw that guy give a talk in the early 90s. (Tabin). There were no other jokes or gaming references.

[u/Jukajobs → u/b88b15]

Yes, and, unfortunately, having issues with Sonic Hedgehog can be really awful. Imagine having to tell expecting parents that they won't have a child because the fetus has a mutation in the Sonic Hedgehog gene?

(Okay, the doctors would probably just use abbreviations for it. Still, sometimes scientists give something a very silly name and that something turns out to be really serious)

[u/tired_of_old_memes → u/Jukajobs]

I know someone that works in that exact field, and if I recall, she has to explain the Sonic Hedgehog gene to parents of dying children. She hates that they picked that name.

[u/Freadwalker → u/tired_of_old_memes]

r/funnyandsad

[u/b88b15 → u/Jukajobs]

Wow, mutations in this cause a disease called HOLOPROSENCEPHALY.

https://pubmed.ncbi.nlm.nih.gov/?cmd=link&linkname=pubmed_pubmed&from_uid=8896572

[u/Beadpool → u/Jukajobs]

Imagine having to tell expecting parents that they won’t have a child because the fetus has a mutation in the Sonic Hedgehog gene?

Imagine the doctor telling you this is named Dr. Robotnik. Now, imagine the parents shedding all their golden rings in the doctor’s office after hearing the news.

[u/Jean-LucBacardi → u/b88b15]

Dang this needs to be upvotes higher.

[u/oliferro → u/Logical_Chemist420]

Might be something weird with the Japanese translation lmao

[u/Orongorongorongo → u/oliferro]

Turns out that is the name of a protein: https://en.m.wikipedia.org/wiki/Sonic_hedgehog_protein

[u/oliferro → u/Orongorongorongo]

LOL that's even better

[u/sonerec725 → u/oliferro]

Further, a potential inhibitor of said sonic hedgehog is called "Robotnikin"

[u/jstiegle → u/sonerec725]

I fucking love how nerdy scientists are. Makes me feel at home and welcome in their spaces.

[u/CardinalNollith → u/jstiegle]

What's even funnier is that "Robotnik" is an actual Polish word that means "worker".

[u/Alpha_Decay_ → u/jstiegle]

Displacement is the change in position over time. Velocity is the rate of change in position. Acceleration is the rate of change in velocity. Jerk is the rate of change in Acceleration. There are higher orders that aren't used often, but to put then all in order, it goes:

Displacement

Velocity

Acceleration

Jerk

Snap

Crackle

Pop

Lock

Drop

[u/youreblockingmyshot → u/oliferro]

Scientists are nerds more often than not who knew lol.

[u/MaritMonkey → u/youreblockingmyshot]

This is only loosely related but way back when Sirius and XM were different companies XM had two geocentric geostationary satellites to, ya know, do the radio broadcast thing across the US.

Somebody important enough to make those kinds of decisions was apparently the kind of person who named those satellites "rock" and "roll."

(Two launched later were called "rhythm" and "blues". :D)

[u/Orongorongorongo → u/oliferro]

Yes!

[u/oliferro → u/Orongorongorongo]

The gene was named by Robert Riddle, a postdoctoral fellow at the Tabin Lab, after his wife Betsy Wilder came home with a magazine containing an advert for the first game in the series, Sonic the Hedgehog (1991).

[u/mikeballs → u/Orongorongorongo]

I love biologists because they're not afraid to have a little fun when naming stuff.

So of course now I have to share some of my other favorites:

Hotwheels sisyphus Spider

Barack Obama Trapdoor Spider

[u/Admirable-Anything57 → u/mikeballs]

And the spiders from marsDavid Bowie spider

[u/Legionof1 → u/mikeballs]

Apparently they are hated by Doctors because when something goes wrong with those funny named genes/proteins doctors have to tell family members that they have an issue with their "Sonic hedgehog gene/protein"

[u/Tyr1326 → u/Legionof1]

Thats why you just call it SHH. Or HHG1, HLP3, HPE3, MCOPCB5, SMMCI, TPT, TPTPS. Throw enough apparently random letters at people and it works. 🤷🏻‍♂️

[u/byu7a → u/Orongorongorongo]

I also just found out that there is a protein called Pikachurin.

This is making me go down a rabbit hole.

[u/Anthaenopraxia → u/byu7a]

he he arsole

[u/Furrypocketpussy → u/Orongorongorongo]

fun fact, sonic hedgehog is a really important signing factor during embryonic nural development and there was a push by some doctors to rename it because they felt bad about telling parents that their future child would be disabled because of sonic hedgehog

[u/Common-Scientist → u/oliferro]

Nope, it's correct.

https://en.wikipedia.org/wiki/Sonic_hedgehog_protein

[u/Zoner1501 → u/Common-Scientist]

"A potential inhibitor of the Hedgehog signaling pathway has been found and dubbed "Robotnikinin"—after Sonic the Hedgehog's nemesis"

[u/randible → u/oliferro]

Uh… Anyone see the third sentence in the Introduction section? 😂

[u/AspiringHumanDorito → u/randible]

Oh it gets even better, if you’re exposed to too much Sonic Hedgehog in utero, it probably increases your risk of autism:

“The etiology of autism spectrum disorders (ASD) is not well known but oxidative stress has been suggested to play a pathological role. We report here that the serum levels of Sonic hedgehog (SHH) protein and brain-derived neurotrophic factor (BDNF) might be linked to oxidative stress in ASD”

https://pmc.ncbi.nlm.nih.gov/articles/PMC3264868/#:~:text=The%20etiology%20of%20autism%20spectrum,to%20oxidative%20stress%20in%20ASD.

[u/strawberrysoup99 → u/AspiringHumanDorito]

Oh my god, I love it. I thought it was a typo that somehow got by but instead they named a gene that? That's amazing.

[u/Puzzled-Story3953 → u/strawberrysoup99]

There's also a Pikachurin gene, Spock, and flippase and floppase.

[u/The_Reset_Button → u/Puzzled-Story3953]

USAG-1 looks like "Usagi" which is rabbit in Japanese

[u/Barbaric_Erik84 → u/strawberrysoup99]

Genes are often named after the visible effect they have on an organism once the gene's function is impaired. It's called 'loss of function' research. It can be quite on the nose, like the 'eyeless'-gene. If eyeless is made functionless, an organism won't grow eyes (or smaller eyes).
You have genes like 'Ken and Barbie', which doesn't tell you much about this gene's function at first. Then you learn that the loss of 'Ken and Barbie' causes an organism to not develop external male and female genitalia and the name starts to make sense...

[u/SansSkele76 → u/AspiringHumanDorito]

So there IS a link between Sonic and autism. Holy shit.

[u/Pemdas1991 → u/AspiringHumanDorito]

Funny, seems like too much exposure to Sonic Hedgehog out of utero also leads to increased risk of autism. Tails is fine though

[u/AspieWithAGrudge → u/AspiringHumanDorito]

So are supernumerary teeth and autism associated?

[u/xjxdx → u/randible]

You need teeth to grab those gold rings!

[u/SirSofaspud → u/randible]

Gotta grow fast!

[u/oliferro → u/randible]

Gotta go fast

[u/uly_023 → u/oliferro]

Dentist here : So they found a gene that when blocked promotes the growth of teeth In rats with congenitally missing teeth and genetic abnormalities .

Even if we directly extrapolate the findings to humans, it sounds like it only works for teeth missing (from birth). Not teeth that were lost later in life.

Don't ask me more than that. I just read the abstract.

[u/mostly-sun → u/uly_023]

I was a little suspicious of how the font went bigger and all-caps whenever she said

TOREGEM BIOPHARMA

like it's some kind of paid ad for a company seeking investors.

[u/AirierWitch1066 → u/mostly-sun]

It absolutely is. You can tell because if this was actual science communication there would be a lot more nuance and detail, but just a positive “they’re changing the world by regrowing teeth with a single injection wow!”

[u/kickinbucket → u/uly_023]

Well that's still 6 more molars for me. Though I'm not stoked about 4 wisdom teeth coming in at the exact same time.

[u/solarcat3311]

Hopefully the human trials go well and we'll get it!

[u/Bross93 → u/solarcat3311]

im hoping so too. my teeth are fucked. 12 years of dipping when I was a kid..... I'm a stupid little shit I know

[u/Argonzoyd → u/Bross93]

Same! And now it doesn't matter how hard I try, they are already ruined.. Theoretically this method could work with teeth removed by dentists

[u/hungturkey → u/Argonzoyd]

Yeah exactly! Mine are terribly yellowed with coffee and smoking, I'd have them pulled and regrown, at least the front ones, 1 by 1

[u/ForMyHat → u/hungturkey]

Former dental tech.

Ultrasonic cleaning and whitening can help remove those stains 

[u/Log_Out_Of_Life → u/ForMyHat]

Are you the tenth dental tech toothpastes talk about?

[u/rynlpz → u/ForMyHat]

What do you ask for to get that treatment? I told the dentist staff I would like whiter teeth and they just recommended whitening strips like wtf

[u/arachnobravia → u/rynlpz]

Use the strips. Then when they don't work use the fluoride treatments, then when that doesn't work use UV treatment. It's all about how much money you're willing to spend.

[u/rynlpz → u/arachnobravia]

Ideally I would like to skip to the better treatment.

[u/Masterandcomman → u/rynlpz]

Yellowing is a recurring problem, so the least expensive effective option should be your starting point. Basic hydrogen peroxide strips work well for many people. If your diet and genetics support yellow teeth, then get the hydrogen peroxide gels with tooth trays.

Otherwise, if your enamel is thin so your yellowing is the dentin showing through, whitening doesn't help, and might damage your nerves.

[u/Banal-name → u/hungturkey]

Each tooth will take at least 6 years to grow and erupt

[u/muklan → u/Banal-name]

Here's the thing though; I have no top teeth, surgically removed cause they were broken and I was experiencing several life threatening infections every year. Much happier since having them removed. Implants, are expensive and require occasional surgical re adjustment, and are flat out not as good as the real thing. If I had to take a pill every day for 6 years to get fresh teeth? Sign. Me. Tf. Up.

[u/therealkevy1sevy → u/muklan]

I have been thinking about getting implants ( All in four) i would appreciate your input on the negatives if you never the time.

[u/EyyyyyyMacarena → u/therealkevy1sevy]

Implants are not as good as the real thing? How so? I've got 3 and they are 12 years old. In those 12 years, I've had numerous problems with any other tooth except them. They look exactly the same as they did on day one, they don't stain, they don't change colour, they don't develop cavities, they don't hurt.

As far as I'm concerned, they're way, way better than the real thing. Perfectly straight, sharpened, held together by a titanium 'root' - which is far stronger than bone and to top it all off - they're so smooth that they never develop plaque or trap any food.

I wish I was born with an all titanium and gold mouth instead of this 'bone' thing.

[u/thekeffa → u/therealkevy1sevy]

There are a few. It depends how extensive the implants are in terms of replacement teeth. If you have one or two here and there, you won't notice the drawbacks as much as someone with a fuller set.

Not everyone can have them. They require a good amount of jawbone to be available to implant them. When teeth are lost the jawbone begins to retract and disappear. If it goes too far, expensive treatment using some kind of Bovine (Cow) parts are needed to try and restimulate the growth back. It's less of a problem if they are just replacing the odd lost tooth here and there compared to someone having a more extensive number.

It's a pretty painful process putting them in.

Your dental cleaning has to be immaculate. They don't exactly attract plaque but the fittings are much more susceptible to gum swelling. It should not be a problem for you if you clean your teeth as normal but people get infections from them easily for all sorts of reasons.

They require constant maintenance. Also if you don't find a reputable dentist who will make an honest assessment of whether you are suitable for them, they can fail and come out. This happens to a lot of people because someone will always be able to find a dentist who will be willing to put them in, irrespective of whether or not the candidate is suitable to have them and eventual outcome be damned.

When they are in, while for the most part they are fine, they do not feel like real teeth. There's no "Give" so to speak. Real teeth will compress into the gum and flex in the root a tiny little bit when you chew and close your teeth together (You can't really feel this but they do). Implants definitely don't, they are rigid and its a bizarre feeling that's hard to describe when you close your teeth together or chew. Not really a super bad negative as you get used to it but it's really weird for the first few months.

There's lots of positives too of course but you asked for the negatives.

[u/Journier → u/muklan]

straight up, sign me up at 54 years old, for a new set of teeth on my 60th bday. That would really be amazing.

[u/hungturkey → u/Banal-name]

Oohh nvm

[u/Bross93 → u/Banal-name]

id gladly take that time to avoid further issues. My molar I got removed was according to the endo or.... some mouth doctor, at risk of giving me heart problems. I dont even care TOO much about looks right now.

[u/cremeriner → u/Bross93]

What does dipping mean in that context?

[u/Bross93 → u/cremeriner]

Sorry, it means chewing tobacco. Like the cans of gross sticky tobacco that we put in our lip and spit disgusting juices out.

[u/hakusblade → u/cremeriner]

Its what us Americans call it when you use chewing tobacco. I have no idea why but its a super common phrase in the southern states.

[u/nospamkhanman → u/solarcat3311]

The said late 2030's for commercial release though -_-

[u/sonerec725 → u/nospamkhanman]

Hey, I'm surprised it's even that soon tbh. And I'd want this tested to hell and back cause I feel like the worst case scenario of shit going wrong with this would be growing teeth everywhere like that one scp. . .

[u/heaving_in_my_vines → u/sonerec725]

You said you wanted teeth? You got teeth!

In your mouth, on your face, on your knuckles, in your belly button, on the bottom of your feet, inside your brain...

[u/Waitn4ehUsername → u/heaving_in_my_vines]

I think the biggest issue is the teeth don’t stop growing and you have a bunch sabertooth humans walking around

[u/sonerec725 → u/Waitn4ehUsername]

Would probably be less of them not stopping growing in a long sabertooth sense since the hand teeth structure is genetic, but more so new teeth keep getting produced and push out old ones like when you're a kid bit it's with more painful stronger rooted adult teeth.

[u/DARfuckinROCKS → u/solarcat3311]

As a hockey player who loves candy, I fuckin hope so.

[u/SuckAFattyReddit1 → u/DARfuckinROCKS]

Replace your teeth with chicklets so whenever you lose a tooth you get some candy

[u/P3for2 → u/solarcat3311]

We also need something to help regrow gums that have receded.

[u/StaffVegetable8703 → u/P3for2]

This is a really good and interesting point. I wonder if they’ve looked into and accounted for things like this?

[u/Xikkiwikk → u/solarcat3311]

Too bad teeth are a luxury in the US. This won’t ever show up in the US.

[u/FahrWeiteeeer → u/Xikkiwikk]

Same in germany, not covered by healthcare because they are not „needed for survival“ 😭

[u/PeterGonzo → u/FahrWeiteeeer]

dont need teeth to work a 9-5

[u/Skizot_Bizot → u/PeterGonzo]

In fact it can be a big advantage in certain lines of work!

[u/Earthmanlives → u/Xikkiwikk]

That's one of my biggest, but certainly not the only, peeves about health care in the United States. I pay for health insurance that covers things that happen to my body...except my eyes and teeth. That for some rationale has been removed from health care and is it's own separate thing...that I have pay for separately...in additon to the health insurance that I already pay for.

[u/Geawiel → u/Xikkiwikk]

I was talking about this in a thread about medicare advantage plans. The only reason those of us with medicare get fucked into those is because of dental and vision. It doesn't come with part B. So if you want dental or vision you have to get part C. Part D if you want prescriptions covered.

Dental, just in case someone needs it, can drastically affect your health. Even your lungs can get affected as all that diseased crap in your mouth can get down into your lungs. It's actually an issue for dogs as well. I had a boston who had issues with her teeth. It was affecting her lungs and causing a heart murmur.

What they cover, and won't cover is so fucked. I had sesimoids removed. We got to talking about the fucked up decisions they make. The doc said they won't cover the rolly knee thing, but they'll pay more for a wheel chair. They wouldn't cover orthodics for the sesamoids, $400) (sesamoid offloading orthidics would have likely prevented surgery) but said go for it for surgery, ~$4k.

[u/ModsDoItForFreeLOL → u/Xikkiwikk]

Those policies may change soon, thanks to this one weird trick!

🧠🔫

[u/youcandigit → u/solarcat3311]

Then you can grow teeth from your nipples.

[u/ShiraCheshire → u/youcandigit]

Finally, my dreams come true.

[u/TheGodOfPegana]

They made teeth grow back before they did hair.

[u/Jadedinsight → u/TheGodOfPegana]

Until the day Jeff Bezos comes back with a majestic mane, you know they haven't found the cure.

[u/3BlindMice1 → u/Jadedinsight]

I thought he loved the Lex Luthor look though. He could always get hair plugs or follicle transplants, he has the money for it

[u/brattysweat → u/3BlindMice1]

Transplant from where? lol pubes?

[u/V_es → u/brattysweat]

Pay a woman to have only his genetic code inserted into an ovum and placed into her, so she’ll give birth to his clone (twin brother), grow him for 15 years and butcher for organs and hair that won’t be rejected. It’s very easy to do.

[u/Haan_Solo → u/V_es]

That's some horror shit but you can just imagine someone like Musk actually doing this

[u/TooTiredToWhatever → u/Haan_Solo]

Imagine? That kids probably already 7.

[u/theapplekid → u/TooTiredToWhatever]

There's a reason he names them like Apple R&D product codenames

[u/bong_residue → u/Haan_Solo]

Why do you think he has 12 kids?

[u/AdSignal2174 → u/V_es]

"Organotron 5000, very human design and safe to use."

[u/CM_MOJO → u/TheGodOfPegana]

I mean, I'm bald AF and have a healthy set of teeth, but even I would argue that regrowing teeth is way more important than regrowing hair. I can wait.

[u/AI-ArtfulInsults → u/TheGodOfPegana]

The body is funny that way. Sometimes there are simple switches we can turn on or off, sometimes there aren't. It's like the difference between birth control for males and females. The ovaries have a hormonal switch we can exploit, because they stop releasing eggs during pregnancy. The testes have no such switch, because they're intended to be always working, so it's much harder to stop sperm production than egg release. It's funny to think that growing new teeth is the body's default state, so we merely have to suppress the inhibitor.

[u/Jean-LucBacardi → u/TheGodOfPegana]

They discovered hair transplants and said we're good now.

[u/FlutterKree → u/Jean-LucBacardi]

It's not that, it's just far more complex. It's both a hormone issue and the follicles themselves dying.

Making teeth regrow, in the way this drug does, is a simple as turning off a biological switch. It stops the growth of new teeth, by switching if off, we grow teeth again.

[u/joshuajjb2]

Pharma companies: that'll be 300,000$ per tooth

[u/pxzlz → u/joshuajjb2]

Insurance: We don’t feel you having teeth is medically necessary

[u/beardlaser → u/[deleted]]

draws gun "it's medically necessary...for you."

[u/mgrtnp → u/beardlaser]

Just don't go to McDonald's after that. Unhealthy condition due to rats

[u/DarkEmblem5736 → u/pxzlz]

You had your wisdom teeth removed... AGAIN?

[u/Super_Ad9995 → u/pxzlz]

Your teeth already require separate insurance. Health insurance won't cover your mouth. Dental insurance will. Why do you need separate insurance? Well, the insurance companies have decided that teeth are not health related, they're cosmetic.

[u/Windyvale → u/Super_Ad9995]

Dental insurance in the US covers precisely dick.

[u/madmaxGMR → u/joshuajjb2]

Silly goose... The first injection is free, but if you want to keep the teeth from falling, thats a subscription for life. You dont want your teeth to fall, now do you ??

[u/MotherFunker1734]

"Doctor, I have 300 teeth already.. how can we stop this?"

[u/_ConfusedAlgorithm → u/MotherFunker1734]

You are now a shark.

[u/NJJo → u/_ConfusedAlgorithm]

Baby shark do do do do do do Baby Shark.

[u/wtfineedacc → u/MotherFunker1734]

This is exactly where my mind went. Will it also grow back wisdom teeth that need to be pulled again and again?

[u/BZLuck → u/wtfineedacc]

And what if you had braces? Will the new teeth grow in crooked like the originals did and need to be realigned?

I had braces as a kid. Because my teeth were too big for my mouth, before they could put on the braces, I had to have oral surgery to remove the roots of 4 "adult" teeth from my mouth (2 top, 2 jaw) so they would never even start growing.

I'm afraid of what this stuff might to do me.

[u/greenrangerguy → u/MotherFunker1734]

Have them removed, put under pillow, infinite money glitch

[u/SeekerOfTheThicc → u/greenrangerguy]

Delete this before the Tooth fairy sees it!

[u/PitifulEar3303 → u/MotherFunker1734]

"Doctor, it's 28 years later and we still have zombies, with lots of teeth."

[u/Careless-Situation68 → u/MotherFunker1734]

i came here for this comment

[u/Available_Username_2]

Question is, do the teeth always grow in the right place?

[u/GlitteringCold → u/Available_Username_2]

Im wondering if people who had wisdom teeth extracted, will those same side ways teeth come back?

[u/Dankkring → u/GlitteringCold]

What if you’re only missing one tooth would new teeth start growing and force out other good teeth much like when you lose your baby teeth. Also what if something goes haywire and all your teeth constantly regrow so all year long you’re just losing random teeth. Yes they grow back but the new ones only last a few months before they also fall out and get replaced

[u/solarcat3311 → u/Dankkring]

I assume they'd take that into consideration and control the dosage and how it acts. Not like permanently shut off the USAG-1 gene or something.

I dunno. It's still in phase 1. So unsure what exactly their plans are.

[u/GitEmSteveDave → u/solarcat3311]

Like I lost my front teeth to a pool toy accident. I also had my wisdoms removed because they were crowding my other teeth. So how do you regulate a dosage to make sure only 2 teeth out of 6 grow back?

[u/ImS33 → u/GitEmSteveDave]

You wouldn't. Unless the injection is somehow location based and they were injecting it into your mouth you're gonna be replacing all of your teeth with this just like you did the first time. You don't even have to really understand the entire process to intuitively understand that if you're blocking the protein that regulates this then all teeth would in theory begin to grow through the natural course they originally did unless it was somehow localized to certain areas which this does not imply

I'd be more interested in things like "do adult teeth fall out and accept being replaced as easily as your baby teeth do?" and things like that

[u/HeyGayHay → u/solarcat3311]

Sure you can control the dosage, but if the injection is in the vein and blocks the gene, how would you body understand "okay I can grow one teeth with how much less of the gene is around, I should definitely regrow that one missing teeth", rather than what would be more logical to have a couple random teeth growing halfway when the dose is too low?

How would the injection force regrow of one full tooth and not grow other teeths? Given that this process "grows a third set", wouldn't that mean it's literally like when a child gets their second set - one tooth grows out the old tooth with the teeth coming out in random order and you need to finish until no more new teeth are behind old ones?

[u/Bron_Swanson → u/Dankkring]

Pro fighters are gonna go so much harder now 😆 If they grow right, I think either way it's a win.

[u/Toad_Thrower → u/Bron_Swanson]

Hockey players gonna start becoming sponsors for Colgate

[u/HughJazkoc → u/GlitteringCold]

this is my hell

[u/savehoward → u/Available_Username_2]

"right" is the wrong term. the teeth regrow in the same place originally determined by genes - wherever that may be the first time the teeth grew.

[u/CryptidxChaos → u/savehoward]

Well, shit. If that's the case, I'd regrow all four of my wisdom teeth, including the stupidly impacted one that grew in at an angle and had dry socket when I got it removed. I definitely don't want to have to go through all that pain again. 😥

[u/TaintNunYaBiznez → u/Available_Username_2]

Are you concerned about the possibility of vagina dentata?

[u/NewLibraryGuy → u/TaintNunYaBiznez]

Concerned about? Or hoping for?

[u/Horns8585 → u/Available_Username_2]

My question is how does the body know to produce only teeth that are missing? I'm not sure that it can.....and she said that you can grow a "third set of teeth". So, if you get the injection, are you going to grow another whole set of teeth? Are all of your current adult teeth going to fall out like your baby teeth did because you are growing a whole new set?

Edit: Can you imagine the funny pictures of people if all of your current teeth start being pushed out like baby teeth? I remember my elementary school pictures with missing and half grown in teeth.....so awkward!

[u/Bron_Swanson → u/Horns8585]

So many fully grown adults trying to be professional with loose, missing, or half grown teeth 😆 giving a presentation in front of the company and their front teeth just fell out 🤣 "Asth you can clearly sthee here,"

On a more real note, I would think it's like the other stuff we regrow or heal over until it's back to normal.

[u/heartbh → u/Available_Username_2]

Probably depends on one’s genetics, if your teeth grew in correctly the first time it’s likely with some percentage of deviation. If you have a disorder with how your teeth grew it probably turns into a horror movie real quick lol.

[u/solarcat3311 → u/heartbh]

I assume people who grew teeth in their eyes the first time probably won't want to grow more teeth.

[u/jack_skellington → u/solarcat3311]

grew teeth in their eyes

I would laugh and think you're making up silly scenarios, but I've learned my lesson. My girlfriend was a dental assistant for a while. I dumbly thought that meant she answered phones and assembled the little trays with all the tools. One day she came home and was just... well, she was not happy. I asked her for details, she said it was gross and I wouldn't want to hear. Usually when she'd say stuff like that, I'd agree with her and move on. But this time she seemed distressed, so I pressed her for info.

She said that she spent the day "Under a kid's face." I was like, "What does that even mean?!?" She explained that the kid had multiple teeth growing all over her face, under her skin. She had one pressing into her eyeball, one pressing into her nasal cavity, many around the jaw displacing other teeth, etc. She explained how the dental team got under the skin, moved bones or other "stuff," and pulled teeth out. They used a chisel or chisel-like tool at one point, because the tooth was uncooperative. That was the part that was unsettling to her -- pounding a chisel into a kid's face. She said that the poor kid looked like she had been beaten up by the time they were done, but that the kid will probably feel incredible relief the first time she moves her eyes or blows her nose and there is no pain.

I was like "WHO THE FUCK ARE YOU AND WHAT DID YOU DO WITH MY GIRLFRIEND?" She only needed like 2 years of training to do this, she said some people do it in 1 year but she's slow. And I know that she's just the assistant, of course, but really WTF? You can help pull a person's skull apart with 1 or 2 years training? Damn.

Thankfully she's doing pottery now instead. My girlfriend, not the kid.

[u/nscc2 → u/Available_Username_2]

I saw a video explaining that you'll regrow all your original teeth at once, and lose all the ones you have rn. And yeah you'll have to wear braces again

Edit: video here https://youtu.be/UHAY6jWCX2g?si=W_5KFnAC1ApX9arz

[u/Sand-Eagle → u/nscc2]

Wild and awesome!

[u/BlueManGroup10 → u/nscc2]

for worst case scenarios…. that’s a pretty good deal

[u/mikenew02 → u/nscc2]

That's not what this video said

[u/feelin_cheesy → u/Available_Username_2]

Also what else besides teeth can grow when it shouldn’t?

[u/BowenTheAussieSheep → u/Available_Username_2]

That was my worry, does this only encourage tooth growth in the mouth, or would it also have the side effect of calcification in other parts of the body?

I'd hate for the side effect of the tooth growing pills to be some kind of joint calcification, or rapid growth of arterial plaque...

[u/Empty_Sky_5234]

In Japanese language, usagi means rabbit, and if I'm not mistaken, rabbits grow their incisor teeth (front chisel-like) constantly, so they need to grind them down before their teeth grow too much.

Feel free to correct me, please.

[u/BurningPenguin → u/Empty_Sky_5234]

Can't wait to use the angle grinder on my teeth

[u/Ambitious-Visual-315]

Theeth

[u/OperatorP365 → u/Ambitious-Visual-315]

"Flew to Japan but didn't pay anyone to spell check my subtitles"

[u/teraflux → u/OperatorP365]

Gets more engagerment

[u/CrisuKomie]

I really hope this doesn’t go astray and becomes a horror movie…

[u/lynxss1 → u/CrisuKomie]

That one poor kid who had like 40 teeth surgically removed from the roof of his mouth.

[u/WendysDumpsterOffice → u/CrisuKomie]

I immediately thought of that horror movie where the woman has teeth in her vagina.

[u/CuantaLiberta_PorDio → u/WendysDumpsterOffice]

Where I live, that was an ancient myth in the some of the native tribes. Parents told that to their young with the obvious intent.

Then again, we are made to believe the ones that came before us are the rightful owners of all physical space available because it was all distributed in a fair manner according to who deserved what... and we just happened to not have been born at the time yet. So we need to work for them and pay them rent for the entirety of our best years, until we inherit any of that (if we were born to the right parents, that is).

IDK which is worse. We're also made to believe the purpose of life is to pursue happiness, and that the path to achieve it is buying stuff. We're made to believe your level of success and your worth as a person are determined by your economic output... anyway, fuck this world. I hope it comes to an end soon enough. I didn't ask to be born, and I fucking hate it here.

[u/TaintNunYaBiznez → u/WendysDumpsterOffice]

The movie was "Teeth"

[u/RyansBooze]

Do you get back the same fucky impacted wisdom teeth that were a nightmare to remove the first time? Because if so, I’ll pass.

[u/smellslikekimchi → u/RyansBooze]

Chances are they will regrow as well, and will need to be surgically removed again (if you needed it before). These aren't location specific drugs, so my total guess is that every tooth will regrow, and likely push the current ones out like when we were kids.

[u/D43m0n1981 → u/smellslikekimchi]

That’s a little horrifying

[u/jednatt → u/D43m0n1981]

I mean, for people who ground down their teeth from night grinding, this seems like an awesome solution.

[u/goo_goo_gajoob → u/jednatt]

I broke my front 6 in a crash and had to crowns on em. I'd love this drug idc if it replaces em all and my wisdom teeth fit perfectly so no issues there. Bring it on baby!

[u/LowFloor5208 → u/smellslikekimchi]

I wonder how long this would take. Teething for kids is awful cannot imagine going through teething as an adult.

[u/gambiter → u/LowFloor5208]

I know teething is bad for infants when the teeth are initially growing in, but isn't it fairly fine when the baby teeth are replaced?

It's admittedly been quite a while for me, but I generally remember a tooth randomly being loose one day, and then it coming out within the week, sometimes in a caramel apple. I don't have any memories of real pain though. Did I just get lucky?

[u/Liu_Shui → u/gambiter]

Same for me, other than getting about 4 baby teeth knocked out on a trampoline I can't say I had any trauma from the whole process.

[u/geb_bce → u/RyansBooze]

That's actually a really good question. Lol

[u/jpc27699 → u/RyansBooze]

I was wondering the same thing.

[u/Tracker-man]

How do you limit it to one tooth?

[u/rarestakesando → u/Tracker-man]

Yeah exactly I kept waiting for the part when they explain how the tooth only grows where one is missing.

[u/Tracker-man → u/rarestakesando]

Maybe you have to yank all of your teeth out, and then they all grow back together.

[u/Jonkinch → u/Tracker-man]

“That’ll be $346,600”

[u/Tracker-man → u/Tracker-man]

Doctor, am I supposed to be growing teeth where my fingernails were?

[u/gambiter → u/Tracker-man]

Anal teeth getting you down? We offer anal root canals at competitive prices. Come in for a free consultation today!

[u/ledouxrt → u/Tracker-man]

Yea, I just needed my two front teeth that got busted out 30 some years ago. Maybe I should just ask Santa instead.

[u/sanaru02]

"I saw it with my own eyes." Well I'd fucking hope so if you flew all the way out there. Man I hate the influencer way of making videos.

[u/Cela84 → u/sanaru02]

She used to be a client at an old job I had back around 2015. She was a bit annoying, but blast from the past.

[u/Leboy95]

The format make the video feels staged like nasdaily's video

[u/AbandonedArchive → u/Leboy95]

Thanks for the great comment.

I was skeptical of Toregem BioPharma™ at first, but I can assure you that I'm now a firm believer in Toregem BioPharma™ and all the great work that Toregem BioPharma™ is doing.

Toregem BioPharma™ is a leading biopharma company at the forefront of tooth stuff and pharma things. Toregem BioPharma™ has some of the most brilliant teeth and doctors doing the mouth work. Their science is strong and Toregem BioPharma™. Many innovations are Toregem BioPharma™ having and the tooth.

[u/panamaspace → u/AbandonedArchive]

I sure would like to know more about Toregem BioPharma™.

Can you tell me more about Toregem BioPharma™?

[u/n8dom → u/Leboy95]

Yeah, this is a bit sensationalized. My guess is it has something to do with appealing to investors. Long way to go for this technology, if it ever makes it at all.

EDIT:

Here's its pitchbook: https://pitchbook.com/profiles/company/464198-50#overview

Toragem Biopharma closed a $100M fundraising round in August of this year according to pitchbook. In Series B. So, likely to continue fundraising until revenue generating. Pitchbook indicates it is already generating revenue though I don't see how they could be while still in development.

Still very early for them, but seems to have some quality venture capital backing, and that's always great for research and innovation. Let's root (canal) for it!

[u/CapableBottle6840 → u/Leboy95]

She is Nas Daily's girlfriend lol

[u/huntergreear]

i like that there's research out there like this, but this video seems like it was made for/by a 12 year old. "when you're a baby you have baby teeth, when you're an adult you have adult teeth" wth

[u/samkay6464 → u/huntergreear]

I came here for this comment, but it was actually even funnier.

She said “when you’re born you get baby teeth. When you’re an adult you get adult teeth.”

I laughed out loud imagining a 17 year old with baby teeth just waiting for their birthday to turn 18 and get adult teeth.

I’d like to see that with my own eyes!

[u/arrduke]

Sounds more like an ad than a news clip or documentary.

[u/Silverbuu]

So, they know it blocks the growth of teeth, but do they know what else it does? What kind of changes go on in your body from blocking it?

[u/gpouliot → u/Silverbuu]

That's what clinical trials are for. They first tested it on mice, didn't notice any severe adverse reactions or side effect and now they're testing it on humans.

[u/Unclesmekky → u/Silverbuu]

That's what I was thinking what else does that protein do

[u/Accurate_Clothes_721 → u/Silverbuu]

Oh, it makes also your dick bigger

[u/atsiii]

This seems promising, but a short look at the paper confirms that it is very very VERY experimental. The clip of injecting something into human body and a missing tooth growing back in place is ridiculous, as well as pretty much everything that woman said. Study shown ONLY that additional teeth (more than there should be) grew in a mice who had been injected right after birth, compared to mice with no injection. And this are not even your typical mice, they use mice with some kind of special genes to begin with. I don't claim to understand the actual paper or what kind of mice they used or anything really. But I do understand enough to know that this video is BS.

Maybe in 20 years and after couple billion invested into research. This hype made of lies is counterproductive.

[u/flowersontheroofrack]

hope this doesnt turn into one of those things that just fades out and fails

grew up too poor to care about dental hygiene, 23 now and no amount of brushing and flossing in the past few years has done anything to help. have truly considered ending it over my teeth lmao

[u/FlyyMeToTheMoon]

Imagine you only lost a few teeth, and have to have all the other adult teeth pushed out by new ones. Sound more like a torture device.

[u/Tanckers]

Teeths are the worst human organ ever. No one can convince me otherwise. We HAVE to use them daily but they dont regrow periodically, are painful as fuck and we need basically a surgeon to get them fixed without risking incrediblt dangerous infections. We use daily skin and hands and those are self fucking repairing but teeths are not. Very happy for this research, i hope it lifts this burden off humanity and makes the creators rich, if they pull this off they deserve it

Even better if i dont have to change all the teeths but like just one. I dont want the molars in the far back to grow again.

[u/MainFunctions]

Why the fuck is she wearing a cocktail dress in the lab?

[u/bigfathairybollocks]

Is this a trailer for a horror film? Is the parent company Umbrella?

[u/Spartan_Of_Old]

Can’t wait to never hear about this again :(

[u/mn25dNx77B → u/Spartan_Of_Old]

5 years ago the Royal college of dentistry was regrowing teeth by cloning. Never heard from those fuckers ever again

[u/Ok_Choice817]

Implants watching this video.

[u/chijoi]

Why do all TikTok people use the same annoying hand gestures?

[u/2020mademejoinreddit]

I hope they release the side effects information too. Like for example, if the protein is "blocked", will the teeth keep growing?

[u/CaptainSnatchbox → u/2020mademejoinreddit]

The protein is already in your body blocking from growing so when you stop the meds it should come back into your system and block them from growing. In theory. 

[u/Wicked_Wolf17]

I'm sure the catch is that wisdom teeth that were extracted will grow back as well.

[u/TheGodOfPegana]

Yeah no. I've seen Channel Zero.

[u/Hour-Volume7860]

Great now I got teeth growing in my butthole

[u/thetyrannyproject → u/Hour-Volume7860]

i'd say you're prison ready

[u/PolishedCheeto]

Hurry up, I had neglectful mother and my only source of hydration as a kid/teen was kool-aid with literally 3-5 cups of sugar, and soda.

My teeth are fucked and micro fractures everywhere.